The ad plays well to the GOP base -- highlighting comments from prominent Democrats that Republicans have taken issue with in the past. And considering the mass exodus of Republicans support for the President since the port deal broke -- the ad will probably help shore up erosion within that base of support.
But the quotes also play well to the Democrats' base.
For independents -- the ad may be a lot of "inside baseball." The point the ad's trying to get across is confusing. I'm not really sure why the GOP is asking Senate Minority Leader Harry Reid to name his party's leader.